Sökning: "Parkinson s Disease"

Visar resultat 21 - 25 av 55 avhandlingar innehållade orden Parkinson s Disease.

1. 21. Search for reliable diagnostic markers for Alzheimer’s disease

   Författare :Niels Andreasen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer´s disease; Mild cognitive impairment; Biochemical markers; Cerebrospinal fluid; Diagnosis; Progression; Tau-protein; Beta-amyloid; Aß42; ApoE; Sensitivity; Specificity;

   Sammanfattning : The diagnosis of Alzheimer’s disease (AD) is rather difficult not at least in the earlier stages of the disease. The diagnostic accuracy has been reported to be around 65-90%. These figures however, come from academic centers with a special interest in the disease and are based on patients followed for several years. LÄS MER

3. 22. Cognitive effects of deep brain stimulation : focus on caudal zona incerta for essential tremor and Parkinson´s disease, and on bed nucleus of stria terminalis for obsessive compulsive disorder

   Författare :Johanna Philipson; Patric Blomstedt; Marjan Jahanshahi; Marwan Hariz; Jean-Luc Houéto; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Deep brain stimulation. Neuropsychology. Cognition. Parkinson’s disease. Essential tremor. Obsessive-compulsive disorder. Caudal zona incerta. Bed nucleus of stria terminalis. Functional MRI.; Neurology; neurologi;

   Sammanfattning : Preserved cognition is an important determinant for perceived Quality of Life (QoL) and has been found to be essential in order to translate improvements in primary symptoms following Deep Brain Stimulation (DBS) into activities of daily living that drive QoL. Therefore, it is important to evaluate not only the clinical improvement, but also the cognitive impact of DBS. LÄS MER

4. 23. On Parkinson's disease and schizophrenia : case control studies, cellular localization and modelling of candidate genes

   Författare :Andrea Carmine; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Genetic; association; dopamine; Parkinson s disease; schizophrenia; retinoid; aldehyde; toxicity;

   Sammanfattning : The causes of many major neurodegenerative, neurodevelopmental and psychiatric diseases are unknown. This thesis has aimed at applying knowledge about the dopamine (DA) neuron system and other key systems to clinical material (DNA and post mortem brain tissue) collected from patients with Parkinson s disease (PD), schizophrenia (SZ) and controls, in order to decipher genetic risk factors. LÄS MER

5. 24. Genetic variation in genes involved in Abeta-degradation in Alzheimer disease

   Författare :Mia Blomqvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer disease; SNPs; genotyping; association study; haplotype; linkage disequilibrium; association mapping;

   Sammanfattning : Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly people and is increasing in prevalence in industrialized societies from 1 to 3 % in 60-65 year-olds to as much as 50 % by age 95. This disease is complex. Multiple genes are involved, and they potentially affect each other. LÄS MER

7. 25. α-Synuclein Fibril Formation and the Effects of Lipid Membranes

   Författare :Ricardo Gaspar; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; alpha-synuclein; Parkinson s disease; microscopic rate constants; Thioflavin T; ganglioside lipids; Exosomes; protein-lipid co-aggregation; model membranes; monomer-dependent secondary nucleation;

   Sammanfattning : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. LÄS MER