Sökning: "Parkinson s Disease"
Visar resultat 11 - 15 av 55 avhandlingar innehållade orden Parkinson s Disease.
11. Emerging pharmacotherapies for Parkinson's Disease: Experimental studies in the rat
Sammanfattning : Parkinson´s disease (PD) is a neurodegenerative disorder characterized by the typical motor symptoms, akinesia/bradykinesia, rigidity and resting tremor. These symptoms are caused by a deficiency of dopamine (DA) in the brain, which depends on degeneration of DA neurons in the substantia nigra. LÄS MER
12. Methods to study glymphatic system in the rodent brain during physiological and pathological processes
Sammanfattning : Over the past decade, our understanding of brain-waste clearance underwent a revolution after the discovery of the so-called glymphatic system. The glia-lymphatic (abbreviated, glymphatic) system was first described in 2012 as a paravascular macrosystem involved in the distribution of nutrients and clearance of metabolic waste from the brain parenchyma. LÄS MER
13. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
Sammanfattning : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. LÄS MER
14. Studies of α-synuclein Oligomers-with Relevance to Lewy Body Disorders
Sammanfattning : The protein alpha-synuclein (α-synuclein) accumulates in the brain in disorders such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). It is believed that the monomeric form of α-synuclein can adopt a partially folded structure and start to aggregate and form intermediately sized oligomers or protofibrils. LÄS MER
15. Development and Characterisation of a Rat Model of Parkinson's Disease
Sammanfattning : Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not validated properly. LÄS MER