Sökning: "Parkinson’s disease PD"

Visar resultat 21 - 25 av 207 avhandlingar innehållade orden Parkinson’s disease PD.

1. 21. Development and Characterisation of a Rat Model of Parkinson's Disease

   Författare :Matilde Negrini; Beteendevetenskapligt laboratorium; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease PD ; behavior; gene therapy; rat model; dopamine; alpha-synuclein; AAV Adeno-Associated virus ; PFFs;

   Sammanfattning : Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not validated properly. LÄS MER

3. 22. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

   Författare :Michael Jewett; Translationell Neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

   Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

4. 23. Stem cell-based models to study cellular alterations in Parkinson’s Disease

   Författare :Margarita Chumarina; Stamcellslaboratoriet för sjukdomsmodellering i det centrala nervsystemet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; stem cells; IPSCs; dopaminergic neurons; oligodendrocytes; omics;

   Sammanfattning : Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. LÄS MER

5. 24. Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases : see(d)ing is believing

   Författare :Anish Behere; Joakim Bergström; Sara Ekmark-Lewén; Martin Ingelsson; Stina Syvänen; Hilal Lashuel; Uppsala universitet; []
   Nyckelord :Alpha synuclein; Tau; Proteoforms; Phosphorylation; Oligomers; Proximity Ligation Assay; sensitive detection of pathology; Alzheimer s disease; Parkinson s disease; pS129; pS202 pT205; pT231; PFFs;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common forms of neurodegenerative disorders affecting approximately 50 million people worldwide. The underlying neuropathological processes leading to AD and PD share many similarities, i.e. aberrant protein aggregation of tau and alpha-synuclein (αSyn) in the brain. LÄS MER

7. 25. On the road to life satisfaction for person's with Parkinsons disease

   Författare :Lina Rosengren; Rehabiliteringsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Life satisfaction; Adaptation; Qualitative approaches; Sense of Coherence;

   Sammanfattning : Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The motor and non-motor symptoms of PD lead to a number of consequences in everyday life for persons with PD (PwPD). LÄS MER