Sökning: "Oligomers"

Visar resultat 1 - 5 av 158 avhandlingar innehållade ordet Oligomers.

  1. 1. Alpha-Synuclein Oligomers : Cellular Mechanisms and Aspects of Antibody Treatment

    Författare :Gabriel Gustafsson; Martin Ingelsson; Joakim Bergström; Anna Erlandsson; Tiago F Outeiro; Marina Romero-Ramos; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Alpha-synuclein; Aggregation; Oligomers; Monoclonal Antibody; Glia; Astrocyte; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. LÄS MER

  2. 2. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

    Författare :Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). LÄS MER

  3. 3. Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy

    Författare :Gustav Östner; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystatin C; amyloid; amyloidosis; oligomers; domain swapping;

    Sammanfattning : The pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. LÄS MER

  4. 4. Computational infrared spectroscopy : Calculation of the amide I absorption of proteins

    Författare :Cesare Michele Baronio; Andreas Barth; Sander Woutersen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; infrared spectroscopy; FTIR; simulation; calculation; amide I; transition dipole coupling; F matrix; protein; amyloid β; oligomers; β-helix; Biophysics; biofysik;

    Sammanfattning : Infrared spectroscopy is an important technique that allows to retrieve structural information from the analysis of absorption spectra. The main application of infrared spectroscopy within life science is the study of the amide I band, which is correlated with protein backbone conformation and, consequently, with the secondary structure of proteins. LÄS MER

  5. 5. Targeting cytotoxic species in amyloid diseases

    Författare :Malin Lindhagen Persson; Anders Olofsson; Lars Tjernberg; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; transthyretin; FAP; amyloid; cytotoxic species; oligomers; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Amyloid diseases are a world-wide problem causing great human suffer and large economical costs. Although amyloid deposits, a common denominator in all amyloid disorders, are detrimental to the surrounding tissue, there is a poor correlation between total amyloid burden and clinical symptoms. LÄS MER