Sökning: "PRR"

Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet PRR.

  1. 6. Developmental role and ligand binding properties of macrophage scavenger receptor MARCO

    Författare :Yunying Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Macrophages express several cell surface receptors, that mediate the recognition of a wide range of endogenous and exogenous ligands. In this manner, macrophages are able to perform their multiple biological functions in regulation of homeostasis and host defense. LÄS MER

  3. 7. Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses

    Författare :Frida Rydnert; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic cells; basophils; allergy; pattern-recognition receptors; allergen-specific immunotherapy;

    Sammanfattning : Allergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. LÄS MER

  4. 8. The zoonotic pathogen Borrelia afzelii in its natural hosts : Bacterial dissemination and immuno-transcriptomics

    Författare :Xiuqin Zhong; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Borrelia afzelii; natural hosts; bacterial load; immune response; RNA-seq;

    Sammanfattning : Most pathogens can infect a number of different host species, but host species often differ considerably in susceptibility to a given pathogen. In the case of zoonotic pathogens, natural hosts typically present little or no disease symptoms, while humans and other “spill-over” hosts often present severe symptoms. LÄS MER

  5. 9. The role and mechanism of ubiquitin system in innate immune regulation

    Författare :Swarupa Panda; Nelson O. Gekara; Fredrik Elgh; Anna Överby; Geert van Loo; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; The ubiquitin system; Deubiquitinase; MYSM1; Innate immune regulation Toll-like receptor; RIG-l like receptors; Cytoplasmic DNA receptors; NOD-like receptors; Francisella tularensis; Immune subversion; molekylärbiologi; Molecular Biology;

    Sammanfattning : Pattern-recognition receptors (PRRs) include the cell surface or endosomal membrane localized Toll-like receptors (TLRs) and the cytoplasmic PRRs such as RIG-I-like receptors (RLRs), NOD-like receptors (NLRs) and cytoplasmic DNA receptors (CDRs). Triggering of PRRs culminates in the transcriptional induction of pro-inflammatory cytokines and type I interferons (IFNs) that coordinate protection against pathogens but require tight control to avert inflammatory diseases. LÄS MER

  7. 10. Polymorphism in pattern recognition receptor genes in pigs

    Författare :Ingrid-Maria Bergman; Inger Edfors; Kristina Nilsson Ekdahl; Kjell Edman; Dag Inge Våge; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; Biomedical Sciences; Biomedicinsk vetenskap;

    Sammanfattning : The mammalian immune defense consists of two systems, which are interconnected and co-operate to provide host defense. The innate immune system is always active and detects and responds to non-self without delay. The adaptive immune system has a lag phase, but is more specific and has got a memory. LÄS MER