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Visar resultat 1 - 5 av 12 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Platelet Inhibition in Coronary Artery Disease – Mechanisms and Clinical Importance : Studies with Focus on P2Y12 Inhibition

    Författare :Christoph Varenhorst; Stefan James; Agneta Siegbahn; Lars Wallentin; Steen Dalby Kristensen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary artery disease; myocardial infarction; acute coronary syndromes; stent thrombosis; P2Y12 inhibitors; thienopyridines; clopidogrel poor response; clopidogrel; prasugrel; Cardiology; Kardiologi; Kardiologi; Cardiology;

    Sammanfattning : Despite the currently recommended dual antiplatelet treatment (DAT) with aspirin and P2Y12 inhibition in patients with coronary artery disease (CAD) there is a risk of adverse clinical outcome. Pharmacodynamic (PD) poor response to clopidogrel occurs in ~ 30% of clopidogrel-treated patients and is associated with an increased risk of recurrent thrombotic events. LÄS MER

  3. 2. Novel Agonists and Antagonists of Platelet Receptors

    Författare :Carl Högberg; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Platelets; P2Y12; SUCNR1; FPP; hypothermia;

    Sammanfattning : Platelets are central for the primary haemostatis. The platelet has surface bound receptors that are vital for the platelet activation. LÄS MER

  4. 3. Impact of chronic total occlusions, arterial access site, and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry

    Författare :Christian Dworeck; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute coronary syndrome; acute myocardial infarction; coronary artery disease; mortality; chronic total occlusion; pretreatment; antiplatelet; P2Y12; radial access; PCI; SWEDEHEART; SCAAR; RIKS-HIA; cardiology;

    Sammanfattning : Impact of chronic total occlusions, arterial access site and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry Background Treatment of ischemic heart disease has advanced substantially in the past half-century. However, despite these achievements the survival rates in high-income countries such as Sweden have reached a plateau in the last decade. LÄS MER

  5. 4. Platelet Inhibition, Revascularization, and Risk Prediction in Non-ST-elevation Acute Coronary Syndromes

    Författare :Daniel Lindholm; Stefan James; Christoph Varenhorst; James de Lemos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary artery disease; myocardial infarction; acute coronary syndrome; non-ST-elevation acute coronary syndrome; P2Y12 inhibitors; ticagrelor; biomarkers; revascularization; percutaneous coronary intervention; risk prediction; Cardiology; Kardiologi;

    Sammanfattning : Cardiovascular disease is the leading cause of death worldwide and ischemic heart disease is the most common manifestation. Despite improved outcomes during the last decades, patients with acute coronary syndromes (ACS) are still at substantial risk of recurrent ischemic events and mortality. LÄS MER

  7. 5. Point-of-care testing of platelet P2Y12-inhibition in patients with acute coronary syndrome

    Författare :Manne Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The point-of-care platelet function test Plateletworks® has been shown to identify patients with high platelet aggregation despite P2Y12 inhibition, also known as high-on-treatment platelet reactivity (HPR), who have increased risk for ischemic cardiovascular events. However, this platelet function assay has not been sufficiently validated. LÄS MER