Sökning: "P Dahlqvist"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden P Dahlqvist.

1. 1. Neuropeptides and neurotrophins in arthritis : studies on the human and mouse knee joint

   Författare :Ola Grimsholm; Sture Forsgren; Solbritt Rantapää-Dahlqvist; Elvar Theodorsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropeptides; neurotrophins; bombesin gastrin-releasing peptide; substance P; brain-derived neurotrophic factor; synovial tissue; knee joint; rheumatoid arthritis; Anatomy; Anatomi;

   Sammanfattning : Neuropeptides, such as substance P (SP) and bombesin/gastrin-releasing peptide (BN/GRP), and neurotrophins are involved in neuro-immunomodulatory processes and have marked trophic, growth-promoting and inflammation-modulating properties. The impact of these modulators in rheumatoid arthritis (RA) is, however, unclear. LÄS MER

3. 2. Quantitative magnetic resonance in diffuse liver and neurological disease

   Författare :Olof Dahlqvist Leinhard; Linköpings universitet; []
   Nyckelord :Mapping--methods; Choline--analysis; Liver diseases--diagnosis; Magnetic resonance imaging--methods; Magnetic resonance spectroscopy--methods; Multiple sclerosis--diagnosis; Multiple sclerosis--metabolism; Nerve fibers; myelinated--metabolism; MEDICINE; MEDICIN;

   Sammanfattning : Magnetic resonance (MR) has become one of the most important diagnostic tools in modern medicine. It provides superior soft tissue contrast compared to other imaging modalities, it is extremely flexible as it can be used to image all parts of the body, and it is considered to be safe for patients. LÄS MER

4. 3. 5-HT2A : a serotonin receptor with a possible role in joint diseases

   Författare :Anders Kling; Solbritt Rantapää-Dahlqvist; Carl-Olav Stiller; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 5-HT2A serotonin receptor; serotonin; rheumatoid arthritis; adverse drug reaction; HTR2A; glucocorticoids; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : BackgroundSerotonin (5-HT), an amino acid derivative and neurotransmitter, has for long been studied in relation to inflammation. It is an endogenous ligand for several different types of serotonin receptors. The serotonin receptor 5-HT2A has been reported to have a role in the pathophysiology of arthritis in animal experiment models. LÄS MER

5. 4. Aspects on inflammation and cardiovascular comorbidity in rheumatoid arthritis

   Författare :Lotta Ljung; Solbritt Rantapää-Dahlqvist; Johan Askling; Piet van Riel; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; co-morbidity; cardiovascular disease; atherosclerosis; acute coronary syndromes; adipokines; adipose tissue; tumor necrosis factor inhibition;

   Sammanfattning : There is an increased risk for cardiovascular (CV) comorbidity among patients with rheumatoid arthritis (RA), with premature atherosclerosis, and a higher incidence of CV events, compared with the general population. Disease related factors add to the CV risk, and interact with the traditional CV risk factors. LÄS MER

7. 5. Insights into the processes preceding the onset of rheumatoid arthritis

   Författare :Linda Johansson; Solbritt Rantapää Dahlqvist; Mikael Brink; Felipe Andrade; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; pre-symptomatic individuals; autoantibodies; anti-citrullinated protein peptides antibodies; Epstein-barr virus; neutrophil extracellular traps; periodontitis; Porphyromonas gingivalis; receptor activator of nuclear factor kappa-B ligand; reumatologi; rheumatology;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by the production of anti-citrullinated protein antibodies (ACPA) in the majority of all patients and a persistent inflammation in the synovial tissue leading to joint destruction. The aetiology of RA remains to a large extent unknown but is believed to be a complex interplay between genetic, environmental and stochastic factors. LÄS MER