Sökning: "pre-symptomatic individuals"
Hittade 5 avhandlingar innehållade orden pre-symptomatic individuals.
1. Insights into the processes preceding the onset of rheumatoid arthritis
Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by the production of anti-citrullinated protein antibodies (ACPA) in the majority of all patients and a persistent inflammation in the synovial tissue leading to joint destruction. The aetiology of RA remains to a large extent unknown but is believed to be a complex interplay between genetic, environmental and stochastic factors. LÄS MER
2. Presence of immunological markers preceding the onset of rheumatoid arthritis
Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease with an unknown aetiology characterized by joint destruction. Both genetic and environmental factors contribute to the disease development with HLA-DRB1* alleles and smoking identified as most important. LÄS MER
3. Study of neurodegenerative diseases with novel MRI techniques
Sammanfattning : Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive degeneration of structure and function of the nervous system. They include diseases such as Alzheimer’s disease (AD), multiple sclerosis (MS) and others. LÄS MER
4. Novel Insights into Inflammatory Disturbed Bone Remodelling
Sammanfattning : Bone is a dynamic tissue that is continuously remodelled, a process that requires equal amounts of osteoclastic bone resorption and osteoblastic bone formation. Inflammation may disturb the equilibrium and result in local and/or systemic bone loss. Negative bone mass balance occurs in several chronic inflammatory diseases, e.g. LÄS MER
5. Hereditary breast/ovarian cancer : implementation of BRCA1 and BRCA2 testing
Sammanfattning : Breast cancer is the most common malignancy among women in the western world. Most cases are sporadic but in 5 to 10 % an inherited genetic mutation is the main cause of the disease. LÄS MER