Sökning: "Over-expression"

Visar resultat 6 - 10 av 138 avhandlingar innehållade ordet Over-expression.

  1. 6. Apoptosis Regulation in Multiple Myeloma

    Författare :Lina Dimberg; Helena Jernberg Wiklund; Kenneth Nilsson; Marie Arsenian Henriksson; Uppsala universitet; []
    Nyckelord :Biomedicine; multiple myeloma; apoptosis; survival; IFN; Stat1; Stat3; IGF-I; RTK inhibitor; PPP; IAP; Fas CD95; dexamethasone; Biomedicin;

    Sammanfattning : Multiple myeloma (MM) is a virtually incurable B cell malignancy of the bone marrow. One important part of tumor progression and an obstacle for successful therapy is resistance to apoptosis. To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. LÄS MER

  3. 7. Regulation of hyaluronan biosynthesis : Expression in vitro and importance for tumor progression

    Författare :Annica Jacobson; Anders Hjerpe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : Hyaluronan, a component of the extracellular matrix, is synthesized by either of three hyaluronan-synthesizing enzymes termed Has1, Has2 and Has3. The expression level of each Has gene varies between cell types of mesenchymal origin and is differentially regulated in response to external stimuli. LÄS MER

  4. 8. Engineering the Secretory Pathway for Recombinant Protein Secretion in Saccharomyces cerevisiae

    Författare :Jichen Bao; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; endoplasmic reticulum; oxidative stress; GLO3; protein secretion; transcriptomics; drug screening; Saccharomyces cerevisiae; SEC16;

    Sammanfattning : In the past few decades there has been an increasing demand of biopharmaceutical proteins in the market. Several types of cell factories are applied to produce different pharmaceutical proteins. LÄS MER

  5. 9. Modeling human germ cell development with pluripotent stem cells and characterizing the putative oogonial stem cells

    Författare :Sarita Panula; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The current understanding of human germ cell development is limited and is at most parts extrapolated from studies of mice or other model organisms. Particularly, the specification events of human germ cell lineage are largely unknown, which is at least in part due to inaccessibility of early stages of human development. LÄS MER

  7. 10. Tachykinin-related peptide signaling and its role in metabolic stress in Drosophila

    Författare :Ryan Tyge Birse; Dick Nässel; Micheal Pankrantz; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurobiology; Neurobiologi;

    Sammanfattning : Tachykinins (TKs) constitute a highly conserved family of multifunctional neuropeptides that are known to be involved in a multitude of functions in mammals. Peptides that are presumed ancestrally related to tachykinins, so called Tachykinin-related peptides (TKRP) have been identified in invertebrates. LÄS MER