Sökning: "O-linked"

Visar resultat 1 - 5 av 21 avhandlingar innehållade ordet O-linked.

1. 1. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

   Författare :Kristina Nyström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

   Sammanfattning : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. LÄS MER

3. 2. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides

   Författare :Jens Frigell; Ian Cumpstey; George Fleet; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbasugar; galactofuranose; mycobacterium; tuberculosis; ring-closing metathesis; GlfT2; galactan; epoxide-opening; pseudodisaccharide; etherification; regioselective; carbohydrate; carbocycles; glycomimetics; glucosidase; neodisaccharides; Mitsunobu; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. LÄS MER

4. 3. O-glycosylation of intestinal and respiratory mucins in health and disease

   Författare :Jessica Holmén Larsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucins; oligosaccharide; O-linked glycosylation; mass spectrometry; MUC2; Fut2 enzyme; Nippostrongylus brasiliensis infection; Cystic Fibrosis; Ulcerative colitis;

   Sammanfattning : Mucins are large glycoproteins with a diverse O-glycosylation constituting up to 80% of the total mucin mass. The mucus layer covering the epithelial cells of the gastrointestinal and respiratory tract is largely made up of gel-forming mucins. LÄS MER

5. 4. Analytical approaches to the study of mucin glycosylation

   Författare :Kristina A Thomsson; Göteborgs universitet; []
   Nyckelord :mucins; O-linked glycosylation; mass spectrometry; cystic fibrosis; salivary mucins; sulfated oligosaccharides.;

   Sammanfattning : Mucins constitute the major protein component of the mucus layer, which covers the epithelial surfaces of the respiratory, the gastrointestinal and the genitourinary tracts. Mucins carry O-linked oligosaccharides which contribute to the molecule by 50-80 weight percent, and these can be highly diverse, with 50-150 different oligosaccharides found on a purified mucin population. LÄS MER

7. 5. Immune recognition and early virus-cell interactions. Glycobiological aspects on HIV-1 gp120

   Författare :Gregers J. Gram; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human immunodeficiency virus type 1 HIV-1 ; glycoprotein; gp120; glycosylation.;

   Sammanfattning : Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in humans. The viral envelope glycoproteins gp120 and gp41 mediate the early virus-cell interaction of HIV with the target cells. LÄS MER