Sökning: "glycomimetics"

Hittade 5 avhandlingar innehållade ordet glycomimetics.

  1. 1. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides

    Författare :Jens Frigell; Ian Cumpstey; George Fleet; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbasugar; galactofuranose; mycobacterium; tuberculosis; ring-closing metathesis; GlfT2; galactan; epoxide-opening; pseudodisaccharide; etherification; regioselective; carbohydrate; carbocycles; glycomimetics; glucosidase; neodisaccharides; Mitsunobu; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. LÄS MER

  3. 2. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors

    Författare :Mukul Mahanti; Centrum för analys och syntes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitors; Glycomimentics; Epimeric switch; MD simulation;

    Sammanfattning : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. LÄS MER

  4. 3. Computational analysis of oligosaccharide conformations – methodological development, applied studies, and design of glycomimetics

    Författare :Francesco Strino; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; histo-blood group antigens; Burkholderia cepacia; genetic algorithms; norovirus; selenoglycosides; sugar conformations; thioglycosides; saccharide conformations;

    Sammanfattning : Carbohydrates are the most abundant class of biomolecules. Besides their roles as structural elements and energy storage, they are involved in signaling and recognition processes. Their functions and activities depend on their preferred conformations. LÄS MER

  5. 4. Norovirus, causative agent of winter vomiting disease, exploits several histo-blood group glycans for adhesion

    Författare :Gustaf E Rydell; Göteborgs universitet; []
    Nyckelord :norovirus; glycobiology; virus-like particle; FUT2; ABO H histo-blood group antigen; sialyl Lewis x; neoglycoprotein; glycosphingolipid; QCM-D; supported lipid bilayer;

    Sammanfattning : Norovirus is recognized as the major cause of outbreaks of gastroenteritis world-wide, yet no vaccines or drugs are available for prevention or treatment of the virus infection. Challenge studies and binding studies using virus-like particles (VLPs) have suggested susceptibility to norovirus infection to be associated with secretor status. LÄS MER

  7. 5. Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions

    Författare :Alexander Dahlqvist; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitor; Heterocycles; C-glycoside; Medicinal chemistry; Organic chemistry; Hydroboration; Diastereoselective; Galactose;

    Sammanfattning : Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. LÄS MER