Sökning: "Human immunodeficiency virus type 1 HIV-1"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden Human immunodeficiency virus type 1 HIV-1.

1. 1. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

   Författare :Sahra Abdulle; Göteborgs universitet; []
   Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

   Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER

3. 2. HIV-1 Exploitation of Dendritic Cell Functionality and Initial Responses in Mucosal Tissues : Elucidation of Influence of HIV-1 Complement Opsonization, and HIV-1-HSV-2 Co-infection

   Författare :Cecilia Svanberg; Marie Larsson; Sofia N. Nyström; Jorma Hinkula; Marianne Jansson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Human immunodeficiency virus (HIV)-1 is transmitted between individuals via sexual intercourse or via blood products. To date there are 38 million people living with chronic HIV infection and around 1.5 million yearly acquire a new infection. LÄS MER

4. 3. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

   Författare :Britt Losman; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

   Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

5. 4. Enhancement of HIV-1 DNA immunogens

   Författare :Anne Kjerrström Zuber; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; DNA vaccination; regulatory genes; adjuvants; experimental HIV-1 model;

   Sammanfattning : Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. LÄS MER

7. 5. Studies on HIV-1 core assembly

   Författare :Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

   Sammanfattning : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. LÄS MER