Sökning: "Natural Unnatural"
Visar resultat 16 - 20 av 42 avhandlingar innehållade orden Natural Unnatural.
16. Rational design of novel cell-penetrating peptides
Sammanfattning : Although cell-penetrating peptides (CPPs) have been an active field of research for over 20 years there are still properties such as efficiency and stability that must be improved for CPPs to reach their full potential as delivery vectors.In this thesis two peptides were designed for non-covalent oligonucleotide delivery, in an attempt to overcome two major issues hampering wider use of CPPs, namely low stability and endosomal entrapment. LÄS MER
17. A Graphical Workstation and Programming Environment for Data-Driven Computation
Sammanfattning : This dissertation reports on the development of a prototype programming environment for a graphical programming language to support a data-driven style of computation. Emphasis is on the need for tools to assist in the development of nontrivial graphical programs. LÄS MER
18. Development and application of new chiral -amino alcohols in synthesis and catalysis : Use of 2-azanorboryl-3-methanols as common intermediates in synthesis and catalysis
Sammanfattning : The development and application of unnatural amino alcohols,prepared via hetero-Diels-Alder reactions,in synthesis and catalysis is described.The studies are concerned with the [i]scope of the hetero-Diels-Alder reaction and preparation of important intermediates in the synthesis of antiviral agents,[ii ]application of amino alcohols in the ruthenium transfer hydrogenation of ketones,[iii ]use of similar precursors in the in situ generation of oxazaborolidines for reduction of ketones,and [iv] development and application of new chiral auxiliaries for dialkylzinc additions to activated imines, respectively. LÄS MER
19. Characterising turbulent ship wakes from an environmental impact perspective
Sammanfattning : The world’s oceans, especially coastal areas, are intensively trafficked by ships. All these ships exert pressure on the marine environment, through emission to the atmosphere, discharges of pollutants to the water, and physical disturbance through energy input. Of these impacts, energy pollution from shipping has received the least attention. LÄS MER
20. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform
Sammanfattning : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. LÄS MER
