Sökning: "Mitochondrial DNA"

Visar resultat 26 - 30 av 262 avhandlingar innehållade orden Mitochondrial DNA.

  1. 26. The interface of mitochondrial DNA transcription and replication

    Författare :Paulina Hannele Wanrooij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria are a dynamic network of subcellular organelles that produce the majority of cellular ATP through the process of oxidative phosphorylation (OXPHOS). The components of the respiratory chain are encoded by two separate genomes, nuclear DNA and mitochondrial DNA (mtDNA), and the proper maintenance of both of these genomic entities is therefore crucial for cellular ATP levels and the survival of the cell. LÄS MER

  3. 27. Biochemical studies of mitochondrial DNA maintenance and topology

    Författare :Direnis Erdinc; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mtDNA maintenance; topoisomerase; replication;

    Sammanfattning : Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, they have their own genetic material, a small circular double-stranded molecule (mtDNA) of 16. LÄS MER

  4. 28. Pathogenic mechanisms affecting mitochondrial DNA replication and transcription

    Författare :Meenakshi Singh; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mtDNA; ribonucleotides; nucleoside analogues; POLRMT;

    Sammanfattning : Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to drive a multitude of cellular reactions. LÄS MER

  5. 29. Mitochondrial dysfunction in neurodegeneration

    Författare :Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

    Sammanfattning : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). LÄS MER

  7. 30. Regulation of Human Mitochondrial DNA Replication and Transcription

    Författare :Majda Mehmedovic; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mtDNA; replication; transcription; TFAM;

    Sammanfattning : Mitochondria are organelles in eukaryotic cells, which through oxidative phosphorylation (OXPHOS) produce most of the ATP used to drive cellular processes. The organelle contains its own genetic material, mitochondrial DNA (mtDNA), which encodes 13 key components of the OXPHOS machinery. LÄS MER