Sökning: "LOH"

Visar resultat 16 - 20 av 56 avhandlingar innehållade ordet LOH.

1. 16. Molecular progression and clonality or urinary bladder cancer

   Författare :Jari Louhelainen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The general aim of this work was to investigate the clonality of multifocal bladder tumours, chromosomal deletions and model the initiation-progression of bladder tumours at a molecular level using microsatellite analysis. In a population-based study, we found correlation between stage and grade and the prevalence of loss of heterozygosity (LOH) at all observed chromosome 13 loci and stage and grade, respectively. LÄS MER

3. 17. Genetic changes in childhood acute lymphoblastic leukaemia and other lymphoid malignancies

   Författare :Teresa Calero Moreno; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Malignant transformation of normal cells is the result of defects in cell growth control, differentiation and programmed cell death. It has been convincingly shown that malignant cells carry mutations in the genes controlling these cellular processes. LÄS MER

4. 18. Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes

   Författare :Jian Liu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tumor suppressor gene; epithelial carcinoma; human chromosome 3p;

   Sammanfattning : Allele loss and deletion mapping using microsatellite markers and the detection of homozygous deletions represented until now the most powerful method to localize potential TSGs. Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by chromosome 3p deletions are detected in almost 100% of renal cell carcinoma (RCC), small (SCLCs) and more than 90% of non-small (NSCLC) cell lung cancers. LÄS MER

5. 19. Molecular genetic analysis of human breast cancer

   Författare :Catherine M Phelan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Breast cancer accounts for approximately 20% of all female malignancies with hereditary breast cancer being implicated in 5-10% of these cases. Two highly penetrant hereditary breast cancer genes are known; BRCA1 (17q) and BRCA2 (13q), which also confer an increased risk of cancer at other sites. LÄS MER

7. 20. Targeting allelic loss in colorectal cancer

   Författare :Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

   Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER