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1. 1. The Biophysics of Na+,K+-ATPase in neuronal health and disease

   Författare :Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

   Sammanfattning : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. LÄS MER

3. 2. Novel aspects of Na+,K+-ATPase

   Författare :Oleg Aizman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Na; K-A TPase; PKA; PKC; dopamine; ouabain; cell attachment; Ca2 ; oscillations; steroid; transcriptional regulation; IP3R.;

   Sammanfattning : Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. LÄS MER

4. 3. Na,K-ATPase as signaling transducer

   Författare :Juan Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. LÄS MER

5. 4. Transport of sodium and protons in the human placenta. Mechanisms in normal pregnancy and alterations in intrauterine growth restriction

   Författare :Martin Johansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; placenta; Na K ATPase; Na H exchanger; H K ATPase; intrauterine growth restriction; BeWo cells; epithelial transport;

   Sammanfattning : The syncytiotrophoblast cell of the human placenta represents the interface between maternal and fetal blood supplies. This polarized epithelium consists of a maternal facing microvillous membrane (MVM) opposing a fetal facing basal membrane (BM). This unique syncytial cell is responsible for transfer of all nutrients to the developing fetus. LÄS MER

7. 5. Role of Na+,K+-ATPase in cell adhesion and cell volume regulation : mutagenesis of Na+,K+-ATPase and transfection in embryonic kidney cell line

   Författare :Roger Belusa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Na ; K -ATPase; adhesion; integrin; cell volume;

   Sammanfattning : The regulation of Na+,K+-ATPase activity by hormones and neurotransmittors via intracellular signaling molecules such as kinases and phosphatases, occurs in several physiological situations in vivo. Alterations of Na+,K+ATPase activity as a result of pathophysiological mechanisms have been shown to be involved in the final outcome of the pathological process. LÄS MER