Sökning: "Joint destruction"

Visar resultat 1 - 5 av 77 avhandlingar innehållade orden Joint destruction.

1. 1. Cartilage destruction - Release of type IX collagen in joint disease

   Författare :Mikael Danfelter; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cartilage destruction; matrix metalloproteinase 13; ECM; assay; neoepitope; NC4 domain; Type IX collagen; fragment;

   Sammanfattning : Cartilage is of vital importance for the function of joints. It is characterized by a prominent extracellular matrix (ECM) that is produced and maintained by relatively few cells of one type, the chondrocyte. LÄS MER

3. 2. Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies

   Författare :Rüdiger J Weiss; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic polyarticular synovial inflammation. Erosive joint destruction represents a major unsolved complication of RA. Objectives: The aim of this thesis was to obtain increased knowledge of joint destruction by using a multidisciplinary approach. LÄS MER

4. 3. Neuropeptides in temporomandibular joint arthritis

   Författare :Anna Appelgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Adjuvant; Arthritis; Calcitonin gene-related peptide; Glucocorticosteroids; Hippocampus; Hyperalgesia; Hypothalamus; Hypothalamo-pituitary-adrenal axis; Intra-articular temperature; Neurokinin A; Neuropeptides; Neuropeptide Y; Nociception; Pain; Pituitary; Pressure pain threshold; Rheumatoid arthritis; Substance P; Synovial fluid; Temporomandibularjoint; Visual analog scale;

   Sammanfattning : Involvement of the peripheral and central nervous systems in the pathophysiology of arthritis has been suggested and neuropeptides are thought to participate in the mediation and modulation of the inflammatory process. The main objective of the clinical studies was to investigate the relationship between the presence of neuropeptides in the synovial fluid of the temporomandibular joint (TMJ) and the stomatognathic symptoms and signs, including the intra-articular temperature (IAT), in patients with TMJ arthritis. LÄS MER

5. 4. Temporomandibular joint involvement by systemic inflammatory disease with reference to pain modulation and joint tissue destruction

   Författare :Ülle Voog; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acute phase proteins; Computed tomography; Cytokines; Granisetron; Inflammation; Pain; Serotonin; Temporomandibular joint; Visual Analogue Scale.;

   Sammanfattning : Systemic inflammatory diseases may cause progressive destruction in the temporo-mandibular joint (TMJ). Involvement of this joint is associated with many clinical signs and symptoms of which pain is a major problem. LÄS MER

7. 5. B cell subpopulations in the pathogenesis of rheumatoid arthritis

   Författare :Katrin Thorarinsdottir; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; Rheumatoid arthritis; Joint destruction; DAS28; CD21- low B cells;

   Sammanfattning : B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG (rheumatoid factor, RF). This demonstrates the vital role B cells play in the disease. LÄS MER