Sökning: "DAS28"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet DAS28.

  1. 1. B cell subpopulations in the pathogenesis of rheumatoid arthritis

    Detta är en avhandling från Göteborgs universitet

    Författare :Katrin Thorarinsdottir; Göteborgs universitet.; Gothenburg University.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; Rheumatoid arthritis; Joint destruction; DAS28; CD21- low B cells;

    Sammanfattning : B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG (rheumatoid factor, RF). This demonstrates the vital role B cells play in the disease. LÄS MER

  2. 2. Exploring a national practice-based register for the management of rheumatoid arthritis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Learning, Informatics, Management and Ethics (Lime)

    Författare :Cheryl Carli; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require on-going contact with health care professionals to ensure adequate management of their disease. LÄS MER

  3. 3. Health economics and its measures in rheumatoid arthritis

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Johan Karlsson; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cost-utility analysis; Cost-of-illness; Quality of life; EuroQol 5-Dimensions; Antirheumatic agents; TNF inhibition; Outcome assessment; Disease activity; Disability; Health economics; Rheumatoid arthritis;

    Sammanfattning : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. LÄS MER

  4. 4. Rheumatoid arthritis in male patients : Sex hormones, bone mineral density and clinical characteristics

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Författare :Birgitta Tengstrand; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; men; gender; testosterone; DHEAS; estrone; estradiol; LH; bone mineral density; outcome.;

    Sammanfattning : The aims of this study were to investigate sex hormones in men with RA and the relation of these hormones with disease characteristics including bone mineral density, as well as to study gender differences in rheumatoid arthritis (RA). Estrogens and androgens and the balance between these hormones interact with the cytokine network and modulate immunity. LÄS MER

  5. 5. Rheumatoid Arthritis: Body Composition, Bone Loss, and Mortality

    Detta är en avhandling från Department of Rheumatology, Lund University

    Författare :Christina Book; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fat mass; bone mass; lean mass; body composition; mortality; rheumatoid arthritis; predictors;

    Sammanfattning : Early rheumatoid arthritis (RA) patients (disease duration ≤1 year, n=165) were recruited 1995-2001 and followed systematically clinically and with dual energy X-ray absorptiometry (DXA) over 2 years and compared to age- and gender-matched controls. Baseline arm and leg lean mass were decreased in RA patients in both genders and body mass index and truncal fat distribution were increased in female RA patients. LÄS MER