Sökning: "Johan D. Söderholm"
Visar resultat 11 - 13 av 13 avhandlingar innehållade orden Johan D. Söderholm.
11. Mechanisms of bacterial-epithelial interaction in Crohn’s disease
Sammanfattning : Crohn’s disease (CD) is believed to be initiated when an individual, who has agenetic predisposition either leading to a disturbance in the barrier functionand/or the innate immune system is exposed to triggering environmentalfactors, the most important being intraluminal bacteria. Genetic and functionalstudies have confirmed the Pattern-recognition receptors (PRRs), Nod2, TLR4and NALP3, as important mediators of the inflammatory process associatedwith disease progression. LÄS MER
12. Bacterial epithelial interaction in intestinal inflammation
Sammanfattning : The intestine is constantly exposed to bacteria, invading viruses and ingested food. The intestinal barrier serves as a gate preventing passage of harmful components, and at the same time maintaining absorption of nutrients and water. LÄS MER
13. Epithelial barrier dysfunction in ileal Crohn's disease
Sammanfattning : The study aimed at investigating the intestinal barrier in Crohn's disease, with special reference to epithelial responses to luminal stimuli, and to permeation of proteins.Ileal mucosa from patients undergoing intestinal resection was studied in vitro in Ussing chambers. LÄS MER