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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Investigating the function of the Receptor Tyrosine Kinase ALK during Drosophila melanogaster development

    Författare :Christina Lorén; Mike Taylor; Umeå universitet; []
    Nyckelord :DAlk; receptor tyrosine kinase; Jeb; visceral muscle fusion; ERK; Drosophila; endoderm; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (DAlk) is homologous to mammalian Alk, which is a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans the t(2;5) translocation involving the Alk locus encodes an active form of Alk that is the causative agent in Non-Hodgkin’s Lymphoma (Morris et al., 1994). LÄS MER

  3. 2. Identification of downstream targets of Alk signaling in Drosophila melanogaster

    Författare :Gaurav Varshney; Ruth Palmer; Udo Hacker; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; Jeb; visceral muscles; somatic muscles; Delilah; Goliath; Hand; Molecular biology; Molekylärbiologi;

    Sammanfattning : The Drosophila gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian ALK, a member of the Alk/Ltk family of receptor tyrosine kinases. In Drosophila Alk is crucial for development of the embryonic visceral mesoderm, where it is the receptor for Jelly Belly (Jeb) ligand. LÄS MER

  4. 3. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

    Författare :Therese Eriksson; Ruth Palmer; Stefan Thor; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. LÄS MER

  5. 4. Investigating the function of Anaplastic Lymphoma Kinase

    Författare :Emma Vernersson Lindahl; Bengt Hallberg; Ruth Palmer; Göran Roos; Carina Hellberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALK; nervous system; knockout; development; Jelly-Belly; Pathology; Patologi;

    Sammanfattning : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. LÄS MER

  7. 5. Deciphering the Alk signaling pathway in Drosophila

    Författare :Fredrik Hugosson; Ruth H. Palmer; Osamu Shimmi; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; RTK; visceral mesoderm; signal transduction; growth factor; transcription factor; molekylärbiologi; Molecular Biology;

    Sammanfattning : In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process where myoblasts become specified to generate two distinct cell types, the founder cells (FCs) and the fusion competent myoblasts (FCMs) that consequently fuses. The cell specification is dependent on cell signaling mediated by the receptor tyrosine kinase (RTK) Anaplastic lymphoma kinase (Alk) and its ligand Jelly belly (Jeb), how this further sets up different identity programs that drive myoblasts to differentiate into FCs and FCMs is still not well understood. LÄS MER