Sökning: "Arp2 3"

Hittade 5 avhandlingar innehållade orden Arp2 3.

  1. 1. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

    Författare :Therese Eriksson; Ruth Palmer; Stefan Thor; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. LÄS MER

  2. 2. Role of PAK4 in pancreas development and breast cancer

    Författare :Miao Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality and mice with conditional PAK4 gene depletion in the heart and in the central nervous system displayed serious organ defects. LÄS MER

  3. 3. Elements in regulation of the microfilament system

    Författare :Louise Hillberg; Uno Lindberg; Theresia Stradal; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cell motility; microfilament system; actin; tropomyosin; Cell and molecular biology; Cell- och molekylärbiologi; Cell Biology; cellbiologi;

    Sammanfattning : This thesis deals with cell motility. The process of rapid actin polymerization in the lamellipodium of a migrating cell is responsible for its protrusion. Studies have been made on some of the elements behind this event and special interest has been focused on the protein tropomyosin. LÄS MER

  4. 4. Cell Behavior and the Role of Profilin

    Författare :Yu Li; Roger Karlsson; Christophe Ampe; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

    Sammanfattning : Profilin is a key regulator of the microfilament system. It binds to actin monomers in a 1:1 complex, forming the profilin:actin complex, which is the major precursor of actin for filament formation in vivo. The distribution of profilin has been studied in a variety of cells. It is present not only in the cytoplasm but also in the nucleus. LÄS MER

  5. 5. Regulation of B cell motility and adhesion in health and disease

    Författare :Lisa Westerberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; B cells; Migration; Adhesion; WASP; immune deficiency;

    Sammanfattning : Migration and adhesion of lymphocytes are crucial to induce an efficient immune response. These activities rely on cytoskeletal dynamics, mediated by assembly of actin and microtubuli monomers leading to changes in cell shape and signaling. LÄS MER