Sökning: "Insulin signaling"

Visar resultat 6 - 10 av 257 avhandlingar innehållade orden Insulin signaling.

  1. 6. Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system

    Författare :Jiangnan Luo; Dick Nässel; Susan Broughton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Insulin; serotonin; octopamine; insulin receptor; Dimm; neuropeptide; funktionell zoomorfologi; Functional Zoomorphology;

    Sammanfattning : In Drosophila, eight insulin-like peptides (DILP1-8) are produced and secreted in different locations. They regulate many aspects of development and physiology, such as organism growth, metabolic homeostasis, reproduction, stress resistance and life span. LÄS MER

  3. 7. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

    Författare :Linda Ahlkvist; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

    Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER

  4. 8. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology

    Författare :Anna Edlund; Henrietta Nielsen; William Rebeck; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; apolipoprotein E; insulin; metabolism; Amyloid precursor protein APP ; Fe65; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER

  5. 9. Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states

    Författare :Siri Aili Fagerholm; Peter Strålfors; Mats Söderström; Ulf Smith; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Increasing numbers of people world-wide develops the disease type 2 diabetes. Development of type 2 diabetes is characterized by a shift from an insulin sensitive state to an insulin resistant state in peripheral insulin responding organs, which originates from the development of insulin resistance in the adipose tissue. LÄS MER

  7. 10. Investigating the role of Class-1 Phosphoinositide 3 Kinases (PI3Ks) in insulin signaling and obesity

    Författare :Angela Molinaro; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin signaling; PI3Ks; PI3K isoform-selective inhibitors;

    Sammanfattning : Obesity and obesity related diseases such as type 2 diabetes, cardiovascular disorders, and different types of cancer are leading causes of mortality and morbidity in modern society. However, the mechanism that links obesity to these diseases remains largely unresolved. LÄS MER