Sökning: "Idiopathic normal pressure hydrocephalus"

Visar resultat 21 - 25 av 26 avhandlingar innehållade orden Idiopathic normal pressure hydrocephalus.

1. 21. Cerebral CT - and MRI perfusion: Techniques and clinical application in iNPH

   Författare :Doerthe Ziegelitz; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebral perfusion; idiopathic normal pressure hydrocephalus; computed tomography perfusion; dynamic suceptibility contrast MRI;

   Sammanfattning : Idiopathic normal pressure hydrocephalus (iNPH) is a disorder of the elderly, defined by slowly progressive impairment of gait and balance, cognitive decline, and incontinence. Disturbance of the cerebrospinal fluid (CSF) dynamics results in ventriculomegaly without intracranial pressure increase. LÄS MER

3. 22. Deriving biomarkers from computed tomography using deep learning

   Författare :Meera Srikrishna; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CT; MRI; convoluted neural networks; deep learning; Dementia; Alzheimer s disease; Normal pressure hydrocephalus; brain segmentation;

   Sammanfattning : X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are widely used structural neuroimaging modalities. For brain atrophy assessment and volumetric quantification using automated methods, MRI is the preferred modality due to its superior soft tissue contrast. LÄS MER

4. 23. Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations

   Författare :Kennet Andersson; Anders Eklund; Karin Wårdell; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinsk teknik; hydrocefalus; infusionstest; utflödeskonduktans; systemidentifiering; Medical technology; Medicinsk teknik;

   Sammanfattning : Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. LÄS MER

5. 24. Altered proteins in the aging brain

   Författare :Adila Elobeid; Irina Alafuzoff; Lena Claesson-Welsh; Thomas Brännström; Uppsala universitet; []
   Nyckelord :Cognitively unimpaired subjects; Hyperphosphorylated tau; Beta amyloid; Alpha-synclein; Transactive response DNA binding protein 43; Patologi; Pathology;

   Sammanfattning : The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). LÄS MER

7. 25. Mitochondria-endoplasmic reticulum contacts in neuronal cells : from physiology to therapeutics

   Författare :Giacomo Dentoni; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mitochondria and the endoplasmic reticulum (ER) are intracellular organelles that play vital physiological functions. Mitochondria are key players in energy production through adenosine triphosphate (ATP) production and calcium (Ca2+) buffering, while the ER is involved in protein and lipid synthesis along with Ca2+ signalling in the cell. LÄS MER