Sökning: "IL4"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet IL4.

  1. 1. Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects

    Författare :Jue Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytochrome P450; CYP2A6; CYP2B6; CYP2El; gene regulation; polymorphism; SNP; genotyping; IL4; signaling pathway;

    Sammanfattning : Cytochrome P450s constitute a superfamily of heme-binding monooxygenases that play important roles in the metabolism of endogenous substrates and a wide variety of exogenous substances, such as toxins and drugs, and participate as well in the biosynthesis of steroids, fatty acids, vitamins and bile acids. The P450s genes are subjects for large inter-individual variability in expression, which subsequently cause inter-individual differences in drug metabolism. LÄS MER

  3. 2. Studies of Ligands and Receptors Regulating Acute Myeloid Leukemia

    Författare :Pablo Peña; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Acute myeloid leukemia (AML) is the most common leukemia in adults and is coupled to a poor prognosis, with a five-year overall survival of around 20% and a high risk of relapse. In AML, immature myeloid cells accumulate rapidly in the bone marrow impairing normal blood cell development. LÄS MER

  4. 3. Functional Screens Identify Vulnerabilities in Acute Leukemia

    Författare :Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

    Sammanfattning : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. LÄS MER

  5. 4. Myeloid cells in autoimmune diseases

    Författare :Muhammad Sohel Mia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple Sclerosis (MS) and Type 1 Diabetes (T1D) are autoimmune diseases caused by dysregulation of the immune system. Monocytes/macrophages are myeloid cells that play a pivotal role in both induction and resolution of these diseases depending on the stage and microenvironment of disease course. LÄS MER

  7. 5. Identification and characterization of candidate therapeutic targets in acute myeloid leukemia

    Författare :Mia Eriksson; Avdelningen för klinisk genetik; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a fatal disease that is characterized by a rapid expansion of myeloid leukemic blasts with impaired differentiation that accumulate in the bone marrow. The prognosis for AML is generally poor, with a five-year overall survival of around 20% in patients over 60 years old. LÄS MER