Sökning: "CYP2El"

Hittade 1 avhandling innehållade ordet CYP2El.

1. 1. Regulation and polymorphism of CYP2A6, CYP2B6 and CYP2E1 : functional and clinical aspects

   Författare :Jue Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cytochrome P450; CYP2A6; CYP2B6; CYP2El; gene regulation; polymorphism; SNP; genotyping; IL4; signaling pathway;

   Sammanfattning : Cytochrome P450s constitute a superfamily of heme-binding monooxygenases that play important roles in the metabolism of endogenous substrates and a wide variety of exogenous substances, such as toxins and drugs, and participate as well in the biosynthesis of steroids, fatty acids, vitamins and bile acids. The P450s genes are subjects for large inter-individual variability in expression, which subsequently cause inter-individual differences in drug metabolism. LÄS MER