Sökning: "Ramprasad Ramakrishnan"

Hittade 1 avhandling innehållade orden Ramprasad Ramakrishnan.

1. 1. Functional Screens Identify Vulnerabilities in Acute Leukemia

   Författare :Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

   Sammanfattning : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. LÄS MER