Sökning: "IFNγ"

Visar resultat 11 - 15 av 45 avhandlingar innehållade ordet IFNγ.

1. 11. Specific and nonspecific immune mechanisms in human gut : a comparative study of normal and ulcerative colitis intestine

   Författare :Moorix Mo-Wai Yeung; Sten Hammarström; Marie-Louise Hammarström; Marita Troye-Blomberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestine; ulcerative colitis; lymphoid aggregates; intraepithelial lymphocytes; lamina propria lymphocytes; γδT-cells; cytokines; IL-2; carcinoembryonic antigen; biliary glycoprotein; epithelial cells; glycocalyx;

   Sammanfattning : The intestine, with its large mucosal surface area, digests and absorbs food nutrients and maintains a beneficial microbial flora in the colon. Local protective immune responses against intestinal pathogens ensure the survival of the individual. These immune reactions are both specific and non-specific in nature. LÄS MER

3. 12. Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

   Författare :Lina Thorvaldson; Stellan Sandler; Michael Welsh; Maria Holstad; Maria Faresjö; Uppsala universitet; []
   Nyckelord :Cell biology; Cytokine; Diabetes; Tumor necrosis factor-α; Interferon-γ; Interleukin-4; Interleukin-10; Transplantation; Pancreatic islet; Glucose; Regulatory T cell; Cellbiologi;

   Sammanfattning : Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. LÄS MER

4. 13. Innate and adaptive immune responses in pulmonary sarcoidosis

   Författare :Maria Wikén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Sarcoidosis is an inflammatory disease characterized by formation of granulomas in various organs and tissues. Although it is a systemic disorder, the lungs are commonly affected, and an infiltration of T cells, in particular CD4pos T helper 1 (Th1) cells, is seen in the lower airways. LÄS MER

5. 14. Immunomodulation and its effector mechanisms in atherosclerosis

   Författare :Charlotta Hjerpe; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Atherosclerosis is a disease of the arterial intima, characterized by cholesterol deposition, inflammation and fibrosis. The pathogenesis of atherosclerosis is related to both innate and adaptive immune responses, and modulation of immune reactions in animal models of atherosclerosis affects the progression of the disease. LÄS MER

7. 15. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma

   Författare :Cecilia Weigelt; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; SAg; SEA; SEAm; HLA class II; TCR; CFL; SDCC; cytotoxicity; TNF a; IFN g; mAb; PA-SEAm; anti-CD19-Fab-SEAm; B-CLL; B-NHL; AML; CML; immunotherapy; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

   Sammanfattning : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. LÄS MER