Sökning: "IFNγ"

Visar resultat 21 - 25 av 45 avhandlingar innehållade ordet IFNγ.

  1. 21. Cytomegalovirus Infection in Immunocompetent and Renal Transplant Patients : Clinical Aspects and T-cell Specific Immunity

    Författare :Fredrik Sund; Britt-Marie Eriksson; Olle Korsgren; Halvor Rollag; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytomegalovirus; renal transplantation; cellular immunity; valacyclovir; mismatched; prophylaxis; tetramer; CD4 T cells; CD8 T cells; Infectious diseases; Infektionssjukdomar;

    Sammanfattning : Cytomegalovirus (CMV) is a β-herpesvirus that, after primary infection, establishes a life-long persistence in the human host. Up to 90% of humans are infected with CMV, that is kept under control by CMV-specific CD8+ and CD4+ T cells. In patients with an impaired cellular immunity, however, CMV infections can be life-threatening. LÄS MER

  3. 22. Long non-coding RNAs in the epigenetic regulation of oligodendrocyte differentiation

    Författare :Samudyata Samudyata; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Long non-coding RNAs (lncRNAs) constitute a heterogeneous class of RNAs with limited coding potential, united by an arbitrarily placed cut off of >200 ntd. The past decade has seen the emergence of lncRNAs as versatile regulators of gene expression, amidst skepticism regarding the biological usefulness of pervasive genomic transcription and its non-coding RNA products prevalent in most eukaryotes. LÄS MER

  4. 23. T cells and chemokines in rheumatoid arthritis

    Författare :Jonathan Aldridge; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; CD4 T cells; chemokines; disease activity; biomarker; CTLA-4Ig;

    Sammanfattning : In this thesis, we investigated if circulating proportions of specific CD4+ T cell subsets and blood chemokine levels were associated with disease activity and/or could predict remission in patients with early rheumatoid arthritis (eRA). We also compared the effect of different biological treatments on both T cell subset proportions and chemokine levels. LÄS MER

  5. 24. Induction of type I interferons and viral immunity

    Författare :Åsa Hidmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Virus-induced type I interferons (IFNα/β) are key mediators of innate immunity and important modulators of adaptive immunity. Early recognition of virus and induction of IFNα/β are important for limiting the spread of the virus. LÄS MER

  7. 25. Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders

    Författare :Priya Sakthivel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Co‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). LÄS MER