Sökning: "Hepatitis C virus HCV infection"

Visar resultat 11 - 15 av 54 avhandlingar innehållade orden Hepatitis C virus HCV infection.

  1. 11. Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection

    Författare :Karolina Rembeck; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C; prognostic factors;

    Sammanfattning : Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. LÄS MER

  3. 12. On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection

    Författare :Åsa Alsiö; Göteborgs universitet; []
    Nyckelord :infectious diseases; virology; hepatitis c; treatment;

    Sammanfattning : Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of considerable side effects and cost, shortened treatment duration without impaired efficacy is desirable. Thus, 382 genotype 2/3 infected patients were randomized in an investigator-initiated phase III study (NORDynamIC) evaluating the efficacy of 12 (short-term) vs. LÄS MER

  4. 13. Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection

    Författare :Galia Askarieh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IP-10; CXCL10; CD26; hepatitis C virus; interferon; ribavirin; treatment; IL28B;

    Sammanfattning : Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. LÄS MER

  5. 14. On the Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : From Tripeptides to Achiral Compounds

    Författare :Pernilla Örtqvist; Anja Sandström; Mats Larhed; Anders Hallberg; Morten Grøtli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C virus; NS3 protease inhibitor; structure-activity relationship; resistance; 2 1H -pyrazinone; phenylglycine; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Infection by the hepatitis C virus (HCV) leads to inflammation of the liver, i.e. hepatitis. The acute infection often progresses to a chronic phase during which the liver function is gradually impaired. LÄS MER

  7. 15. Hepatitis C virus infection : molecular analysis of transmission and immunity

    Författare :Tobias Allander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hepatitis C virus; Nosocomial transmission; Hemodialysis; Leukemia Envelope glycoprotein gp70; Hypervariable region 1; Antibodies; Phage display; Combinatorial antibody libraries; Neutralization.;

    Sammanfattning : Hepatitis C virus (HCV) is an important cause for chronic liver disease worldwide. Infection by HCV may resolve spontaneously, but in the majority of cases a chronic infection is established, that may result in liver cirrhosis and hepatocellular cancer. LÄS MER