Sökning: "Helena Wiklund"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Helena Wiklund.

  1. 1. Growth regulation and proto-oncogene expression in human multiple myeloma cell lines in vitro

    Författare :Helena Jernberg-Wiklund; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. Evolution of annelid diversity at whale-falls and other marine ephemeral habitats

    Författare :Helena Wiklund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Whale-fall; cryptic species; Dorvilleidae; Chrysopetalidae;

    Sammanfattning : When whales die and sink to the sea-floor, they provide a sudden, enormous food supply to organisms in the vicinity. At first, larger mobile scavengers remove the flesh, but also when only the bones remain, the whale-fall can still sustain macrofauna communities for several years. LÄS MER

  4. 3. Life history evolution in a bivoltine butterfly

    Författare :Helena Larsdotter Mellström; Christer Wiklund; Klaus Fischer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bivoltine; Diapause; Lepidoptera; Life history; Mating system; Pheromone; Polyphenism; Population density; Sexual selection; Sperm competition; zoologisk ekologi; Animal Ecology;

    Sammanfattning : Evolution is not always straight-forward, as selection pressures may differ between different generations of the same species. This thesis focuses on the evolution of life history of the model species, the Green-veined White butterfly Pieris napi. In central Sweden P. napi has two generations per year. LÄS MER

  5. 4. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental Approaches

    Författare :Prasoon Agarwal; Helena Jernberg Wiklund; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; Integrative bioinformatics; Epigenetics; CGGBP1; RNA polymerase; Oncology; Onkologi; Bioinformatik; Bioinformatics;

    Sammanfattning : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). LÄS MER

  7. 5. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma : Implications for Biology and Therapy

    Författare :Mohammad Alzrigat; Helena Jernberg-Wiklund; Fredrik Öberg; Kristina Drott; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple Myeloma; Epigenetics; Polycomb; PRC2; PRC1; EZH2; BMI-1; UNC1999; PTC-209; Epigenetic Therapy; Medicinsk vetenskap; Medical Science; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/plasma cells. MM is characterized by extensive genetic and clonal heterogeneity, which have hampered the attempts to identify a common underlying mechanism for disease establishment and development of appropriate treatment regimes. LÄS MER