Sökning: "Helena Nordström"

Hittade 5 avhandlingar innehållade orden Helena Nordström.

  1. 1. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Helena Nordström; Helena Danielson; Gregg Siegal; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

    Sammanfattning : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. LÄS MER

  2. 2. Parkinson’s disease the prodromal phase and consequences with respect to working life

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Helena Nyström; Anna Nordström; Peter Nordström; Kristian Winge; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; quality of life; employment; rehabilitation; prodromal phase; risk markers; depression; muscle strength; injurious fall; epidemiology;

    Sammanfattning : Background: Parkinson’s disease (PD) is a common, progressive neurodegenerative disorder, recognized by the motor symptoms of bradykinesia, tremor, rigidity, and postural impairment. At clinical onset, extensive amounts of dopaminergic neurons have already been lost. LÄS MER

  3. 3. Polymeric Nanoparticles as Carriers for Antimicrobial Peptides Factors Affecting Peptide and Membrane Interactions

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Randi Nordström; Martin Malmsten; Per Hansson; Helena Bysell; Erica Wanless; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptide; microgel; degradable; nanogel; drug delivery; PEGylation; secondary structure; model membrane; lipid bilayer; neutron reflectometry; ellipsometry; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Sammanfattning : As resistance towards conventional antibiotics is becoming more pronounced, cationic antimicrobial peptides (AMPs) have received considerable attention as possible therapeutic alternatives. Thousands of potent AMPs occur in humans, animals, plants and fungi as a natural part of the immune system. LÄS MER

  4. 4. Incentives and Inequalities in Family and Working Life

    Detta är en avhandling från Uppsala : Department of Economics, Uppsala University

    Författare :Aino-Maija Aalto; Helena Svaleryd; Oskar Nordström Skans; Mårten Palme; [2018]
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Career Choices; Role Models; STEM; Childcare; Child Health; Unemployment; Quasi-Experiment; Parental Leave Reform; Labour Market Participation; Economics; Nationalekonomi;

    Sammanfattning : Essay I: Same-gender teachers may affect educational preferences by acting as role models for their students. I study the importance of the gender composition of teachers in math and science during lower secondary school on the likelihood to continue in math-intensive tracks in the next levels of education. LÄS MER

  5. 5. Use of energy-signature method to estimate energy performance in single-family buildings

    Detta är en avhandling från Luleå : Luleå tekniska universitet

    Författare :Gustav Nordström; [2014]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Träbyggnad; Timber Structures;

    Sammanfattning : The renewal of the existing housing stock is a slow progress and theexisting is quite old. The existing housing stock represents a largeamount of the bought energy need for heating and a simple method forquickly determining the energy performance is needed.There are many different methods for estimating the energyperformance of buildings. LÄS MER