Sökning: "Helena Nordström"

Hittade 5 avhandlingar innehållade orden Helena Nordström.

  1. 1. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

    Författare :Helena Nordström; Helena Danielson; Gregg Siegal; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

    Sammanfattning : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. LÄS MER

  3. 2. Parkinson’s disease : the prodromal phase and consequences with respect to working life

    Författare :Helena Nyström; Anna Nordström; Peter Nordström; Kristian Winge; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; quality of life; employment; rehabilitation; prodromal phase; risk markers; depression; muscle strength; injurious fall; epidemiology;

    Sammanfattning : Background: Parkinson’s disease (PD) is a common, progressive neurodegenerative disorder, recognized by the motor symptoms of bradykinesia, tremor, rigidity, and postural impairment. At clinical onset, extensive amounts of dopaminergic neurons have already been lost. LÄS MER

  4. 3. Polymeric Nanoparticles as Carriers for Antimicrobial Peptides : Factors Affecting Peptide and Membrane Interactions

    Författare :Randi Nordström; Martin Malmsten; Per Hansson; Helena Bysell; Erica Wanless; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptide; microgel; degradable; nanogel; drug delivery; PEGylation; secondary structure; model membrane; lipid bilayer; neutron reflectometry; ellipsometry; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Sammanfattning : As resistance towards conventional antibiotics is becoming more pronounced, cationic antimicrobial peptides (AMPs) have received considerable attention as possible therapeutic alternatives. Thousands of potent AMPs occur in humans, animals, plants and fungi as a natural part of the immune system. LÄS MER

  5. 4. Incentives and Inequalities in Family and Working Life

    Författare :Aino-Maija Aalto; Helena Svaleryd; Oskar Nordström Skans; Mårten Palme; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Career Choices; Role Models; STEM; Childcare; Child Health; Unemployment; Quasi-Experiment; Parental Leave Reform; Labour Market Participation; Economics; Nationalekonomi;

    Sammanfattning : Essay I: Same-gender teachers may affect educational preferences by acting as role models for their students. I study the importance of the gender composition of teachers in math and science during lower secondary school on the likelihood to continue in math-intensive tracks in the next levels of education. LÄS MER

  7. 5. Att styra mot uthållig organisatorisk samverkan i hälso- och sjukvårdsprocesser : Främjande och motverkande faktorer

    Författare :Margareta Karlsson; Rickard Garvare; Birgitta Nordström; Helena Ranängen; Anders Fundin; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kvalitetsteknik och logistik; Quality technology and logistics;

    Sammanfattning : Svensk hälso- och sjukvård står inför utmaningar att möta ändrade behov, nya behandlingsmetoder och ny teknik. Genom samordning och samverkan antas kvaliteten för patienten kunna förbättras samtidigt som kostnader reduceras. LÄS MER