Sökning: "HLADRB1*"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet HLADRB1*.

  1. 1. The role of anti-collagen type II antibodies in the pathogenesis and prognosis of rheumatoid arthritis

    Författare :Vivek Anand Manivel; Johan Rönnelid; Arne Egesten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; Anti-collagen type II antibodies; HLADRB1*; Granulocytes; prognosis; ;

    Sammanfattning : Rheumatoid arthritis (RA) which affects 0.5-1% of the world population and is characterised by joint erosions and presence of the autoantibodies anti-citrullinated protein antibodies (ACPA) and rheumatoid factor. LÄS MER

  3. 2. Genetic regulation of neuroinflammation : a translational approach

    Författare :Johan Öckinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), causing demyelination and axonal damage. As other complex diseases with an inflammatory or autoimmune component, MHC is a strong regulator of the disease and acts in concert with multiple nonMHC genes and environmental factors. LÄS MER

  4. 3. Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation

    Författare :Sofia Ernestam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; cytokines; gold sodium thiomalate; TNF-antagonists;

    Sammanfattning : Rheumatoid arthritis (RA) is a systemic inflammatory disease primarily affecting the joints. In the pathogenesis several cells of the immune systeme and messengers of the immune systeme, cytokines, are important. LÄS MER

  5. 4. Mixed connective tissue disease, myositis and systemic lupus erythematosus : immunological and genetic studies in three related rheumatic autoimmune studies

    Författare :Adla Bakri Hassan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MCTD; SLE; PM DM; autoantibodies; cytokines; MHC; polymorphisms.;

    Sammanfattning : Mixed connective tissue disease (MCTD), polymyositis (PM)/ dermatomyositis (DM) and systemic lupus erythematosus (SLE) are chronic, rheumatic, systemic inflammatory disorders. The disorders depend on several factors of both genetic and environmental origin. LÄS MER

  7. 5. Anti-citrulline immunity in rheumatoid arthritis : characterization of peptide-HLA interactions and CD4+ T cell responses

    Författare :Christina Gerstner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid Arthritis (RA) is a complex, systemic autoimmune disorder characterized by chronic inflammation in small joints in hands and feet. It is a common disease that if untreated leads to joint destruction, disability, comorbidities and a reduced lifespan. LÄS MER