Sökning: "TNF-antagonists"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet TNF-antagonists.

  1. 1. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Författare :Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Sammanfattning : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. LÄS MER

  3. 2. Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects

    Författare :Meliha C Kapetanovic; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; muskelsystem; reumatologi; Skeleton; muscle system; rheumatology locomotion; ANA; infusion reaction; influenza vaccination; pneumococcal vaccination; COMP; TNF antagonists; spondylarthropathies; arthritis; rheumatoid arthritis;

    Sammanfattning : Abstract The treatment of arthritis has undergone a dramatic change since biological agents targeting specific mediators of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. LÄS MER

  4. 3. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability

    Författare :Lars Erik Kristensen; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; response; drug survival; psoriatic arthritis; Arthritis; rheumatoid arthritis; adverse events; TNF antagonists;

    Sammanfattning : Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. LÄS MER

  5. 4. Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation

    Författare :Sofia Ernestam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Rheumatoid arthritis; cytokines; gold sodium thiomalate; TNF-antagonists;

    Sammanfattning : Rheumatoid arthritis (RA) is a systemic inflammatory disease primarily affecting the joints. In the pathogenesis several cells of the immune systeme and messengers of the immune systeme, cytokines, are important. LÄS MER

  7. 5. Studies of the synovial membrane in chronic rheumatic joint disease

    Författare :Erik af Klint; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The synovial membrane (SM) outlines the inner cavity of synovial joints except for cartilage surfaces. The SM is the target organ of immune-mediated responses in chronic arthritis, including rheumatoid arthritis (RA). RA is a common joint disease (prevalence of 0.5-1. LÄS MER