Sökning: "nelfinavir"

Hittade 4 avhandlingar innehållade ordet nelfinavir.

  1. 1. Antiretroviral treatment of HIV-1 in the central nervous system

    Författare :Aylin Yilmaz; Göteborgs universitet; []
    Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Sammanfattning : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. LÄS MER

  3. 2. Prevention of mother-to-child transmission of HIV-1 by antiretroviral treatment and the impact on maternal health in Dar es Salaam, Tanzania

    Författare :Matilda Ngarina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes the results of the Mitra Plus study, including the outcome of antiretroviral therapy (ART) for preventing mother-to-child transmission (PMTCT) of HIV-1 in breastfeeding women and improving HIV-free survival (Paper I), treatment outcome of women initiated on ART for life (Paper II) and reasons for poor drug adherence (Paper III) in Dar es Salaam, Tanzania. Another study (qualitative in nature) explored women’s preferred treatment option for the prevention of breast milk transmission of HIV (Paper IV). LÄS MER

  4. 3. Kinetics of HIV-1 drug resistance mutations in vivo

    Författare :Veronica Svedhem Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; anti-retroviral therapy; drug resistance; therapy failure; rebound; persistence; wildtype virus; SPCR; minor population;

    Sammanfattning : Antiretroviral therapy (ARV) exert a selective pressure on HIV-1 and may select viral drug resistant strains which have competitive advantage in the presence of the drug. Knowledge about the appearance and disappearance of these mutations is important when choosing ARV. LÄS MER

  5. 4. Prevention of mother-to-child transmission of HIV-1 using antiretroviral drugs in Dar Es Salaam, Tanzania

    Författare :Charles Kilewo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes studies of prevention of mother-to-child transmission (MTCT) of HIV-1 in breast-feeding populations in sub-Saharan Africa by perinatal and postnatal prophylactic antiretroviral therapy (ART) of mothers and infants. The acceptability of HIV counseling and testing in pregnant women and the mortality among HIV-1-infected women during 2 years after delivery was also studied. LÄS MER