Sökning: "beta2-microglobulin"

Hittade 4 avhandlingar innehållade ordet beta2-microglobulin.

  1. 1. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

    Författare :Sahra Abdulle; Göteborgs universitet; []
    Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

    Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER

  3. 2. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

    Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER

  4. 3. Follicular lymphoma : clinical and biological factors associated with response to therapy and overall prognosis

    Författare :Sandra Johanna Young Lockmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Follicular lymphoma (FL) is a heterogeneous group of malignancies within the adaptive immune system. The clinical course is highly variable. Treatment includes different chemotherapy regimens as well as the anti-CD20 monoclonal antibody rituximab which has significantly improved the prognosis for patients with all types of B cell lymphomas. LÄS MER

  5. 4. Influence of Ly49 inhibitory receptors and MHC class I on T cell and NK cell function

    Författare :Linda Öberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cell; T cell; Ly49; MHC class I;

    Sammanfattning : Natural Killer cells (NK) can kill virus infected cells and tumor cells but do not harm normal surrounding cells. The function of Ly49 receptors on NK cells is important in maintaining selftolerance since they transmit inhibitory signals when bound to endogenous MHC class I molecules. Their role in T cells is however unclear. LÄS MER