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Visar resultat 11 - 15 av 21 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. The Myc network of growth regulators and its interplay with growth and differentiation signals

    Författare :Siqin Wu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; p21Cip1; phorbol ester; IFN-g; TGF-b; differentiation; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. LÄS MER

  3. 12. Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients

    Författare :Amir Osman Abdalla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Idiotype; vaccination; multiple myeloma; T cell response;

    Sammanfattning : In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently under evaluation as a novel alternative or complementary therapy in many cancer types. LÄS MER

  4. 13. Immunological and molecular studies for the development of vaccine therapy for chronic lymphocytic leukemia

    Författare :Marzia Palma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukaemia (CLL) is a malignant lymphoproliferative disorder which typically affects elderly people. It is the commonest leukemia in the Western adults, accounting for 25-30% of all leukemias and for 10% of all hematological neoplasms. LÄS MER

  5. 14. Matrix metalloproteases and cell motility in malignant mesothelioma

    Författare :Zhiwen Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Matrix; metalloproteases MMPs ; cell motility; growth factors; malignant mesothelioma; invasion;

    Sammanfattning : Invasion and metastasis of malignant tumor cells requires destruction of and migration through extracellular matrix (ECM) such as basement membrane and interstitial stroma. The ECM-degrading proteases produced by tumor cells and stromal cells and cell motility play a crucial role in this process. LÄS MER

  7. 15. Cancer vaccine strategies and studies of human thioredoxin reductase splice variants

    Författare :Pascal Dammeyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer involves abnormal, uncontrolled proliferation of cells, and evasion from the immune system. Immune evasion can be caused by defects in one or more of the components of the major histocompatibility complex class I antigen machinery, e.g. the beta2-microglobulin (beta2m) molecule. LÄS MER