Sökning: "Glucocorticoid receptor"

Visar resultat 31 - 35 av 95 avhandlingar innehållade orden Glucocorticoid receptor.

  1. 31. Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids

    Författare :Thomas Meyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :glucocorticoid receptor; osteocalcin; gene regulation; TATA box element;

    Sammanfattning : Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. LÄS MER

  3. 32. Intracellular signaling in the lung : a role for C/EBP transcription factors in chronic obstructive pulmonary disease, glucocorticoid signaling and lung development

    Författare :Lukas Didon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Over the last decade, a previously unknown role has been established for members of the C/EBP transcription factor family in lung gene expression. In other organs, C/EBPs are well known regulators of cell differentiation and linked processes such as proliferation, apoptosis, gene expression as well as central regulators of inflammatory responses and infectious defenses. LÄS MER

  4. 33. Nuclear hormone receptors studied by molecular dynamics computer simulations

    Författare :Peter Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear hormone receptor; glucocorticoid; molecular dynamics; simulation; ligand; coactivator; protein; solvation;

    Sammanfattning : Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. LÄS MER

  5. 34. Nucleosome positioning : impact on transcription factors access

    Författare :Qiao Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :glucocorticoid receptor; transcription factor; gene regulation; nucleosome; nucleosome positioning; DNA-bending sequence;

    Sammanfattning : In the eukaryotic cell nucleus, DNA is organized into nucleosomes. Some of the regulatory regions are integrated into sequence-specifically positioned nucleosomes. LÄS MER

  7. 35. Corticosteroid receptors and Na,K-ATPase in the developing mouse cochlea

    Författare :Susan Erichsen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :inner ear; stria vascularis; endolymph production; Na; K-ATPase; glucocorticoid receptor; mineralocorticoid receptor; knockout mouse; shaker-2; mix; immunohistochemistry;

    Sammanfattning : The senses of hearing and equilibrium are highly dependent on the fluid and electrolyte homeostasis in the inner ear. The characteristic intracellular-like ionic composition of endolymph fluid in relation to the surrounding perilymph creates the endocochlear potential (EP), which is a prerequisite for inner ear function. LÄS MER