Sökning: "mineralocorticoid receptor"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden mineralocorticoid receptor.

1. 1. Mineralocorticoid receptor antagonists in heart failure : exploring the gap between guideline-directed medical therapy and real-world practice

   Författare :Anna Jonsson Holmdahl; Krister Lindmark; Helena Norberg; Ellinor Bergdahl; Fredrik Valham; Niklas Bergh; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Mineralocorticoid receptor antagonists; estimated glomerular filtration rate; hyperkalemia; impaired renal function; worsening renal function; guideline-directed medical therapy; kardiologi; Cardiology;

   Sammanfattning : Heart failure is the possible end-result of a variety of different diseases, where ischemic heart disease and hypertension are the most common causes in high income countries. In Sweden, heart failure has a prevalence of 2% in the adult population and rises to over 10% among people over 70 years of age. The 5-year all-cause mortality is about 50%. LÄS MER

3. 2. Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism

   Författare :Anita Christiane Hansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Neurotrophins; BDNF; NT-3; bFGF; FGF receptor; immediate early genes; c-fos; antisense oligodeoxynucleotides; adrenalectomy; stress; glucocorticoids; mineralocorticoids; glucocorticoid receptor; mineralocorticoid; receptor in situ hybridization.;

   Sammanfattning : Gluco- and mineralocorticoid hormones exert powerful actions on brain function and are important in the mediation of the stress response and the survival of hippocampal neurons. The aim of this thesis was to study the influence of glucocorticoid (GR)/mineralocorticoid receptor (MR) actions on brain neurotrophism including analyses of immediate early genes (IEGs) and of feedback responses on GR and/or MR. LÄS MER

4. 3. Functional analysis of ligand recognition by the glucocorticoid receptor

   Författare :Ulrika Lind; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glucocorticoid receptor; steroid-binding; site-directed mutagenesis; protein-ligand interaction; mechanism of glucocorticoid action;

   Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. LÄS MER

5. 4. Corticosteroid receptors and Na,K-ATPase in the developing mouse cochlea

   Författare :Susan Erichsen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :inner ear; stria vascularis; endolymph production; Na; K-ATPase; glucocorticoid receptor; mineralocorticoid receptor; knockout mouse; shaker-2; mix; immunohistochemistry;

   Sammanfattning : The senses of hearing and equilibrium are highly dependent on the fluid and electrolyte homeostasis in the inner ear. The characteristic intracellular-like ionic composition of endolymph fluid in relation to the surrounding perilymph creates the endocochlear potential (EP), which is a prerequisite for inner ear function. LÄS MER

7. 5. Post-Ischemic Housing Conditions Influence On Gene Transcription And Translation After Permanent Focal Brain Ischemia In Rats

   Författare :Li-Ru Zhao; Sektion IV; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; brain-derived neurotrophic factor; mRNA; nerve growth factor-induced gene A; corticosteroid receptors; in situ hybridization; Neurologi; neurophysiology; Neurology; neuropsychology; brain ischemia; enriched environment; neuropsykologi; neurofysiologi;

   Sammanfattning : Enriched environment (EE) housing significantly ameliorates neurological deficits induced by cortical brain ischemia without changing infarction size, suggesting that EE-related functional benefits are associated with neuronal plasticity events in the remaining tissue. Brain-derived neurotrophic factor (BDNF), nerve growth factor-induced gene A (NGFI-A) and corticosteroid receptors (mineralocorticoid receptor, MR; glucocorticoid receptor, GR) have been demonstrated to be involved in brain plasticity. LÄS MER