Sökning: "coactivator"

Visar resultat 1 - 5 av 38 avhandlingar innehållade ordet coactivator.

  1. 1. Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer

    Författare :Sara Alkner; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; prognosis; treatment prediction; endocrine treatment; tamoxifen; coactivator; AIB1; PAX2; SRC; contralateral breast cancer; premenopausal; randomized trial; mode of detection; mammography.;

    Sammanfattning : One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. LÄS MER

  3. 2. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1

    Författare :Anita Popko-Scibor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. LÄS MER

  4. 3. Nuclear hormone receptors studied by molecular dynamics computer simulations

    Författare :Peter Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear hormone receptor; glucocorticoid; molecular dynamics; simulation; ligand; coactivator; protein; solvation;

    Sammanfattning : Nuclear hormone receptors form a super family of homologous transcription factors. The liganddependent nuclear receptors are important drug targets controlling metabolic and inflammatory disorders, amongst others. LÄS MER

  5. 4. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER

  7. 5. Molecular mechanisms of gene activation by nuclear receptors and their associated coregulators

    Författare :Anette Wärnmark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors (NRs) are ligand-dependent transcription factors. The DNA-bound receptors either positively or negatively regulate transcription of target genes. The receptors regulate transcription through interaction with transcription coregulators and recruitment of components of the basal transcription machinery. LÄS MER