Sökning: "Glucocorticoid receptor"
Visar resultat 16 - 20 av 95 avhandlingar innehållade orden Glucocorticoid receptor.
16. Leukocyte-derived matrix metalloproteinase-9 in patients with coronary artery disease : Associations with psychological stress and glucocorticoid sensitivity
Sammanfattning : Inflammation is closely associated with development of atherosclerosis. The proteolytic enzyme matrix metalloproteinase (MMP)-9 is considered to play a prominent role in this process. MMP-9 has also been introduced as a marker for plaque vulnerability. LÄS MER
17. Determinants of ligand-induced nuclear receptor activation
Sammanfattning : The nuclear receptors (NRs) constitute a highly conserved superfamily of transcription factors restricted to metazoans. In general, these receptors are regulated by small lipophilic molecules such as steroids, thyroid hormones and retinoids and play an important role in cellular regulation. LÄS MER
18. Gluco- and mineralocorticoid receptor regulation of regional brain neurotrophism
Sammanfattning : Gluco- and mineralocorticoid hormones exert powerful actions on brain function and are important in the mediation of the stress response and the survival of hippocampal neurons. The aim of this thesis was to study the influence of glucocorticoid (GR)/mineralocorticoid receptor (MR) actions on brain neurotrophism including analyses of immediate early genes (IEGs) and of feedback responses on GR and/or MR. LÄS MER
19. The glucocorticoid receptor as a regulator of cortisol responses in cortisol resistant patients and healthy subjects
Sammanfattning : Glucocorticoids are essential for life, and are involved in growth, reproduction, intermediary metabolism, immune and inflammatory reactions as well as central nervous system and cardiovascular functions. Glucocorticoids are also used as treatment of many diseases. LÄS MER
20. Modulation of nuclear receptor function by interacting proteins
Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER