Sökning: "Giampaolo Merlini"

Hittade 2 avhandlingar innehållade orden Giampaolo Merlini.

1. 1. Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis

   Författare :Joakim Bergström; Per Westermark; Giampaolo Merlini; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; Amyloid; Fibril; Aggregation; Apolipoprotein A-IV; Transthyretin; Seeding; Senile systemic amyloidosis; Familial amyloidotic polyneuropathy; Patologi; Pathology; Patologi;

   Sammanfattning : Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. LÄS MER

3. 2. Heparan Sulfate Dependent Mechanisms of Amyloidosis

   Författare :Fredrik Noborn; Jin-ping Li; Ulf Lindahl; Giampaolo Merlini; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amyloidosis; Heparan sulfate; Transthyretin; Serum amyloid A; Amyloid-beta; lipoproteins; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : A common theme in amyloid disorders is the deposition of disease-specific protein aggregates in tissues. Amyloid proteins bind to heparan sulfate (HS), a sulfated glycosaminoglycan, and HS has been found to promote the aggregation process. LÄS MER