Sökning: "Funktionsgenomik"

Visar resultat 11 - 15 av 64 avhandlingar innehållade ordet Funktionsgenomik.

1. 11. Demography and Polyploidy in Capsella

   Författare :Kate St.Onge; Anna Palmé; Martin Lascoux; Ulf Lagercrantz; Richard Abbott; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Approximate Bayesian Computation; Mating system; Brassicaceae; flowering time; genetic diversity; Evolution; Biology; Biologi;

   Sammanfattning : Studies of demography and population structure give insight into important evolutionary processes such as speciation and diversification. In the present work I perform such studies in the genus Capsella, which has three species: C. grandiflora, an outcrossing diploid, C. rubella a selfing diploid, and C. LÄS MER

3. 12. Integrative Modeling of Epigenetic Regulation in Human Disease

   Författare :Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

   Sammanfattning : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. LÄS MER

4. 13. Molecular Tools for Detection and Characterization of Proteins and Extracellular Vesicles in Health and Disease

   Författare :Ehsan Manouchehri Doulabi; Masood Kamali-Moghaddam; Lucia Mincheva-Nilsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-resolution mass spectrometry; Proximity ligation assay; Proximity extension assay; Thymidine kinase 1; in situ PLA; High-throughput.; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Detecting molecules involved in cancer is critical for cancer research and diagnostics. To achieve this goal, sensitive protein detection is essential to improving the chances of finding, verifying, validating and developing valuable biomarkers. LÄS MER

5. 14. The role of hematopoietic chromosome Y loss in health and disease

   Författare :Jonas Mattisson; Lars A. Forsberg; Jonatan Halvardson; Adam Ameur; Andrea Ganna; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; loss of chromosome Y; LOY; mosaic loss of chromosome Y; mLOY;

   Sammanfattning : Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation, and affected men have increased risk for all major causes of death, including cardiovascular diseases and cancer. As a male specific mutation, it helps explain why men live shorter lives than women. LÄS MER

7. 15. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution

   Författare :Mengqi Wang; Ulf Landegren; Anders Ståhlberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homogenous serological assay; PCR-based antibody detection; Proximity extension assay; SARS-CoV-2 antibody; Extracellular vesicles; Proximity barcoding assay; in situ superRCA; mutant transcript;

   Sammanfattning : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. LÄS MER