Sökning: "FLT3"

Visar resultat 16 - 20 av 52 avhandlingar innehållade ordet FLT3.

  1. 16. Strategies to overcome drug resistance in FLT3+ AML

    Författare :Jingmei Yang; Ran Friedman; Merja Heinäniemi; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Sammanfattning : Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor survivalrate and limited therapeutic options. Targeted treatment of other types ofcancer, for instance chronic myeloid leukemia (CML) and breast cancer, has seensignificant progress. LÄS MER

  3. 17. Differentiation factor Fms-like tyrosine kinase 3 ligand is a modulator of cell responses in autoimmune diseases

    Författare :Mats Dehlin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Flt3-L; rheumatoid arthritis; primary Sjögren s syndrome;

    Sammanfattning : Fms-like tyrosine kinase 3 (Flt3) is a receptor on common stem cell progenitors and has a crucial role in hematopoesis, regulating cell proliferation and differentiation in man and mice. The growth factor Flt3 is activated by its soluble ligand, Flt3-L, leading to differentiation of multipotent stem cells and lymphoid progenitors. LÄS MER

  4. 18. Studies on myeloid differentiation: cytokine influence and identification of a novel marker gene

    Författare :Karin Dannaeus; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; MYADM; stem cell factor; Flt3 ligand; Hematopoiesis; Hematologi; extracellulära vätskor;

    Sammanfattning : Hematopoiesis is a highly complex process by which a range of specialized blood cells are generated from a small pool of multipotent stem cells in the bone marrow. The survival, proliferation, and differentiation of hematopoietic stem cells are tightly regulated by both soluble and membrane-bound cytokines produced within the bone marrow microenvironment. LÄS MER

  5. 19. Roles of hematopoietin and cytokine tyrosine kinase receptors in early lymphopoiesis

    Författare :Christina Jensen; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL -7; FLT3 Ligand; cytokines; lymphopoiesis; hematopoiesis; TSLP; apoptosis;

    Sammanfattning : Cytokines have been shown to have important roles in lymphopoiesis. However, many questions remain unresolved. Among other, while the action of interleukin (IL)-7 in alpha beta T cell development in mouse seems to be largely mediated through permissive survival signaling, the possible permissive role of IL-7 in early B cell development is disputed. LÄS MER

  7. 20. Studies on the normal and oncogenic signaling networks from the hematopoietic growth factor receptors c-Kit and Flt3

    Författare :Kristina Masson; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The closely related receptor tyrosine kinases c-Kit and Flt3 are mainly expressed in hematopoietic cells and are involved in driving cell proliferation and promoting survival in response to growth factor stimulation. Several gain-of-function mutations of both c-Kit and Flt3 have been found in malignancies like acute myeloid leukemia, gastrointestinal stroma tumors and small cell lung carcinomas, and the constitutively activated receptors are very potent oncogenes. LÄS MER