Sökning: "FLT3"

Visar resultat 11 - 15 av 52 avhandlingar innehållade ordet FLT3.

  1. 11. Mechanisms of therapy resistance in acute lymphoblastic leukemia

    Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

  3. 12. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

    Författare :Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

    Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER

  4. 13. Prognostic markers in pediatric leukemia and mechanisms of KRAS induced leukemogenesis

    Författare :Anna Staffas; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prognostic markers; AML; T-ALL; leukemia; FLT3; NPM1; ERG; BAALC; KRAS;

    Sammanfattning : Leukemia results from uncontrolled growth of genetically altered blood cells. Depending on the cell type of origin, the leukemia is defined as T-cell, B-cell, or myeloid and as acute or chronic depending on its characteristics. However, patients with a certain subtype of leukemia (e.g. LÄS MER

  5. 14. The FLT3 Tyrosine Kinase in Leukemia : Deciphering the Downstream Signaling Events and Drug-Escape Mechanisms

    Författare :Amanda Nordigården; Jan-Ingvar Jönsson; Mickael Sigvardsson; Alexander Vener; Bengt Hallberg; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a severe disease, which originates in blood-forming cells. Although major advances in understanding the biology of AML, the majority of patients eventually succumb to the disease. LÄS MER

  7. 15. FLT3 and KIT in acute myeloid leukemia. Translational studies on oncogenic signaling from receptor tyrosine kinases. : Translational studies on oncogenic signaling from receptor tyrosine kinases

    Författare :OSCAR LINDBLAD; Avdelningen för translationell cancerforskning; []
    Nyckelord :Acute myeloid leukemia; FLT3-ITD; KIT; tyrosine kinase receptors;

    Sammanfattning : .... LÄS MER