Sökning: "Kristina Masson"

Hittade 1 avhandling innehållade orden Kristina Masson.

1. 1. Studies on the normal and oncogenic signaling networks from the hematopoietic growth factor receptors c-Kit and Flt3

   Författare :Kristina Masson; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The closely related receptor tyrosine kinases c-Kit and Flt3 are mainly expressed in hematopoietic cells and are involved in driving cell proliferation and promoting survival in response to growth factor stimulation. Several gain-of-function mutations of both c-Kit and Flt3 have been found in malignancies like acute myeloid leukemia, gastrointestinal stroma tumors and small cell lung carcinomas, and the constitutively activated receptors are very potent oncogenes. LÄS MER