Sökning: "Einar B. Ólafsson"

Hittade 1 avhandling innehållade orden Einar B. Ólafsson.

1. 1. Signaling determinants in Trojan horse-mediated dissemination of Toxoplasma gondii

   Författare :Einar B. Ólafsson; Antonio Barragan; Eva Frickel; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apicomplexa; leukocyte motility; dendritic cell; amoeboid migration; host-parasite interactions; podosome; integrin; ITGB1; ECM; MAT; TIMP; MMP; MAPK; Erk; RTK; HGFR; Ras; calcium; VDCC; VGCC; calmodulin; CaMkII; CD63; FAK; SRC; Pi3k; hypermigration; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Toxoplasma gondii is an obligate intracellular parasite that infects all warm-blooded vertebrates including one third of the global human population. While infection is typically asymptomatic in healthy human hosts, reactivated and acute infection in immunosuppressed or immunecompromised individuals can lead to lethal toxoplasmic encephalitis After ingestion, the parasite crosses the intestinal epithelium and rapidly achieves systemic dissemination, ultimately establishing chronic infection in the brain. LÄS MER