Sökning: "VGCC"
Hittade 3 avhandlingar innehållade ordet VGCC.
1. Signaling determinants in Trojan horse-mediated dissemination of Toxoplasma gondii
Sammanfattning : Toxoplasma gondii is an obligate intracellular parasite that infects all warm-blooded vertebrates including one third of the global human population. While infection is typically asymptomatic in healthy human hosts, reactivated and acute infection in immunosuppressed or immunecompromised individuals can lead to lethal toxoplasmic encephalitis After ingestion, the parasite crosses the intestinal epithelium and rapidly achieves systemic dissemination, ultimately establishing chronic infection in the brain. LÄS MER
2. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells
Sammanfattning : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. LÄS MER
3. Environmental input to the pancreatic β-cells - the role of mechanosensitive and other ion channels
Sammanfattning : Compound input from genetic predisposition, environmental factors and lifestyle lead to beta-cell dysfunction which initiates the development of type 2 diabetes. Understanding the linkage between the environmental input and gene regulatory pathways controlling beta-cell function is key for developing novel therapies against T2D. LÄS MER