Sökning: "Drug Combinations"

Visar resultat 6 - 10 av 99 avhandlingar innehållade orden Drug Combinations.

  1. 6. Quantifying effects of antimicrobial drug combinations by modelling and simulation

    Författare :Chenyan Zhao; Lena Friberg; Elisabet I. Nielsen; Shampa Das; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics and pharmacodynamics; modelling and simulation; antibiotic combination; model-based translation; antibiotic resistance; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Antibiotic resistance is becoming an accelerating issue, both in the treatment of nosocomial infections and for public health in general. There is a pressing need for innovative methods to understand how available antibiotics could be combined to overcome and limit the emergence of resistance. LÄS MER

  3. 7. Vaccination against drug-resistant HIV

    Författare :Andreas Boberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Combinations of antiretroviral drugs against human immunodeficiency virus type 1 (HIV-1) have effectively postponed the progression to acquired immunodeficiency syndrome (AIDS). However, an effective vaccine against HIV-1 would undisputedly be the optimal protective strategy against the virus, especially in resource-poor settings. LÄS MER

  4. 8. Teenage Kicks – The Differential Development of Drug Use, Drunkenness, and Criminal Behaviour in Early to Mid-Adolescence

    Författare :Russell Turner; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drug use; Drunkenness; Alcohol intoxication; Criminal behaviour; Delinquency; Adolescence; Adolescent development; Risk behaviour; Risk factor; Prevention; Critical realism; realist method; Person-oriented method;

    Sammanfattning : This thesis studies the development of drug use, drunkenness, and criminal behaviour in early to mid-adolescence. Its main aims are to improve knowledge about how and why these three behaviours develop and to contribute towards the development of theory that can have applications in prevention policy and practice. The thesis comprises four studies. LÄS MER

  5. 9. Modeling of combination therapy to support drug discovery in oncology

    Författare :Tim Cardilin; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pharmacokinetics Pharmacodynamics; Oncology; Nonlinear Mixed-Effects Models; Model-Based Drug Development; Combination Therapy;

    Sammanfattning : Mathematical models based on ordinary differential equations, with impulses, are used to describe tumor growth after different treatment combinations, including chemicals as well as radiation. The models are calibrated, using a nonlinear mixed-effects framework, based on time series data of tumor volume from animal experiments. LÄS MER

  7. 10. CYP2C19 polymorphisms in drug metabolism and response

    Författare :Ming Chang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. LÄS MER