Sökning: "DNA-binding proteins"

Visar resultat 16 - 20 av 137 avhandlingar innehållade orden DNA-binding proteins.

  1. 16. Influence of cisplatin on RNA structure in solution Escherichia coli tRNA(Ala) and human Wnt-5a 3' UTR model system studies

    Författare :Pal Papsai; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemi; metabolism; Proteins; enzymology; Proteiner; enzymologi; Metabolism; Biochemistry; Naturvetenskap; Natural science; tRNA.; siRNA; probing RNA structure in solution; alanyl-tRNA synthetase; cisplatin;

    Sammanfattning : RNA molecules in the cellular environment have several important functions. In many cases, proper RNA function is intimately linked to proper three-dimensional structure of the molecule. Thus, it seems reasonable to assume that structural changes caused by external influence can strongly inhibit important cellular functions maintained by RNAs. LÄS MER

  3. 17. Studies of glucocorticoid receptor interacting proteins

    Författare :Christina Widén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glucocorticoid receptor (GR) functions as a ligand dependent transcription factor. Nonliganded GR resides mainly in the cytoplasm bound to a complex containing heat shock proteins (hsp). LÄS MER

  4. 18. DNA-Complexes with Drugs and Proteins

    Författare :Louise Fornander; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Circular Dichroism; Linear Dichroism; Minor groove binder; DNA strand exchange; HsRad51; Isothermal Titration Calorimetry; Hoechst 33258;

    Sammanfattning : DNA is fundamental for all living cells; the DNA holds the genetic code, which is more or less the instruction book for how all cells are built and function. Several diseases are also linked to DNA, emerging either from a mutation in our genome, which could result in a malfunctioning protein, or that the transcription of genes is somehow affected by structural changes in the DNA, induced by mutations or DNA binding molecules. LÄS MER

  5. 19. NMR studies of DNA/RNA-binding proteins

    Författare :Helena Berglund; KTH; []
    Nyckelord :;

    Sammanfattning : This thesis concerns the structure and internal dynamics inDNA and RNA-binding proteins. While it has long been known thata proper three-dimensional structure is essential for aprotein's ability to interact with other biomolecules, theinfluence of the inherent protein dynamics is less wellunderstood. LÄS MER

  7. 20. Modulation of nuclear receptor function by interacting proteins

    Författare :Waffa Osman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors are a family of transcription factors involved in many biological processes. They represent key potentials as therapeutic targets for several clinical conditions such as diabetes, obesity, cardiovascular disease and cancer, because their activity is modulated by small molecules. LÄS MER