Sökning: "DNA-binding proteins"

Visar resultat 11 - 15 av 137 avhandlingar innehållade orden DNA-binding proteins.

1. 11. Gene regulation by the glucocorticoid receptor : post-DNA binding mechanisms of transcriptional activation

   Författare :Tova Almlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Gene activation; Glucocorticoid receptor; Nuclear receptor; Transactivation domain; Transcription; Transcription factor; Yeast;

   Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the nuclear receptor family. The GR has important functions in cellular differentiation, development and metabolism in higher eukaryotes. LÄS MER

3. 12. Altered proteins in the aging brain

   Författare :Adila Elobeid; Irina Alafuzoff; Lena Claesson-Welsh; Thomas Brännström; Uppsala universitet; []
   Nyckelord :Cognitively unimpaired subjects; Hyperphosphorylated tau; Beta amyloid; Alpha-synclein; Transactive response DNA binding protein 43; Patologi; Pathology;

   Sammanfattning : The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). LÄS MER

4. 13. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies

   Författare :Gunnel Henriksson; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; 18 ; t 14; cell cycle; p53; DNA-PK; DNA-binding protein; hypermutation; Sjögren s syndrome; DNA damage; anti-CD4 antibodies; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

   Sammanfattning : Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. LÄS MER

5. 14. A novel method using DNA binding fluorochromes as indirect probes to study linker histone-chromatin interactions in situ

   Författare :Helena Loborg; Pierre Åman; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Over the years, a variety of methods have been used to study chromatin structure. These techniques have provided valuable information about nuclear framework, chromatin organisation, and the proteins that are involved in the formation and maintenance of chromatin. LÄS MER

7. 15. Electron crystallography of soluble proteins

   Författare :Matthew James Ellis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Interfacial crystallization; electron microscopy; image processing; soluble protein; phospholipid layer;

   Sammanfattning : Protein structures at moderate to high resolution can now be readily solved using an electron microscope and image processing techniques. The averaging conditions required to overcome the low signal to noise ratio of electron microscope images are particularly well satisfied by two-dimensional crystals. LÄS MER